{"id":1995,"date":"2023-03-22T08:16:29","date_gmt":"2023-03-22T08:16:29","guid":{"rendered":"https:\/\/insekten-biotechnologie.de\/?page_id=1995"},"modified":"2023-05-08T09:54:25","modified_gmt":"2023-05-08T09:54:25","slug":"probiocontrol","status":"publish","type":"page","link":"https:\/\/insekten-biotechnologie.de\/en\/probiocontrol\/","title":{"rendered":"ProBioControl"},"content":{"rendered":"

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ProBioControl:<\/strong><\/h1>\n

Profilierung von Naturstoff-produzierenden Mikroorganismen f\u00fcr die Isolierung neuer antifungaler Naturstoffe und deren potentielle Anwendung als Biokontrollmittel<\/p>\n

 <\/p>\n

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Forschungsmotivation und Problemstellung<\/h2>\n

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Die konventionelle Landwirtschaft in Deutschland ist f\u00fcr nahezu die gesamte Belastung der Umwelt mit chemischen Pflanzenschutzmitteln verantwortlich. Mit ca. neun kg\/ha\/Jahr f\u00fchrt die Nutzung dieser PSM zu einem Verlust an Biodiversit\u00e4t, der Vernichtung von Lebensr\u00e4umen und der Manifestation von Pestiziden in Nahrungsketten. Zus\u00e4tzlich verursacht die Landwirtschaft 7,5% der deutschen Treibhausgas-Emissionen und ist damit ein Treiber des Klimawandels.<\/p>\n

Die Rate des Biodiversit\u00e4tsverlusts und der globalen Erw\u00e4rmung haben bereits ein kritisches Limit \u00fcberschritten. Dies f\u00fchrt zu extremen klimatischen Ereignissen wie langen und h\u00e4ufigeren Trockenperioden und starken Regenf\u00e4llen und schw\u00e4cht die deutschen \u00d6kosysteme. In dieser angespannten Situation sind Pflanzensch\u00e4dlinge auf dem Vormarsch.<\/p>\n

Um diesen Entwicklungen entgegenzuwirken ist eine Transformation und Neuausrichtung der landwirtschaftlichen Systeme in Richtung einer bio\u00f6konomisch vertr\u00e4glichen, nachhaltigen Lebensmittelproduktion unumg\u00e4nglich. Ein wesentlicher Bestandteil dessen sind Bestrebungen den \u00f6kologischen Landbau zu f\u00f6rdern. Doch gerade dieser Form des Anbaus mangelt es an Bek\u00e4mpfungsmitteln gegen\u00fcber Pflanzenpathogenen. Dies f\u00fchrt zu einer Verwundbarkeit des gesamten Sektors.<\/p>\n

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Projektziele und L\u00f6sungsansatz<\/h2>\n

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Einen wesentlichen Faktor f\u00fcr hohe Ertragsverluste stellen Pilzkrankheiten im \u00d6kolandbau dar. Eine Reihe von \u00f6kologisch anwendbaren Biokontrollmitteln sind auf dem Markt erh\u00e4ltlich, jedoch fehlt in vielen F\u00e4llen das Wissen \u00fcber ihre genaue Wirkweise.<\/p>\n

Ziel des Projektes ist es, mikrobielle St\u00e4mme zu identifizieren und zu charakterisieren, die als antifungale Biokontrollmittel verwendbar sind. Basis ist dabei die 120.000 Mikroorganismen umfassende Stammsammlung des Fraunhofer IME.<\/p>\n

Zwei wichtige Pilzkrankheiten in Deutschland sollen in diesem Zusammenhang adressiert werden: die Septoria-Blattd\u00fcrre als die weltweit verbreitetste Krankheit bei Weizen und die Schwarzfleckenkrankheit bei Kartoffeln, welche besonders durch den Klimawandel profitiert.<\/p>\n

Dabei werden detaillierte Kenntnisse \u00fcber die metabolischen und genomischen Eigenschaften der neuen St\u00e4mme erzeugt. So wird bisher mangelndes Wissen generiert, welche metabolischen F\u00e4higkeiten zur Funktionalit\u00e4t von Biokontrollmitteln beitragen. Zus\u00e4tzlich werden Tests einbezogen um L\u00f6sungen mit g\u00fcnstigem \u00f6kologischen und toxikologischen Profil zu identifizieren.<\/p>\n

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Vorgehensweise<\/h2>\n

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Die fungiziden Eigenschaften von bodenbewohnenden Bakterien als nat\u00fcrlichen Bestandteilen der Boden\u00f6kosysteme werden erforscht.\u00a0 Dazu werden modernste Metabolomik- und Genomik-Technologien eingesetzt um die metabolischen F\u00e4higkeiten der hier untersuchten Bakterien umfassend zu bestimmen. Dies wird in einem dreiphasigen Projekt umgesetzt:<\/p>\n

 <\/p>\n

    \n
  1. Identifizierung und Charakterisierung von Bakterien, die ein vielversprechendes Naturstoffprofil aufweisen. Geleitet durch antifungale Bioaktivit\u00e4tsdaten wird das metabolische Profil der St\u00e4mme erfasst und bewertet. Dadurch kann sowohl die Produktion von pflanzenf\u00f6rdernden Substanzen als auch sch\u00e4dlichen Stoffwechselprodukten erkannt werden.<\/li>\n
  2. Neue Naturstoffe mit antifungaler Aktivit\u00e4t werden isoliert und ihre Struktur aufgekl\u00e4rt. Die identifizierten St\u00e4mme und Naturstoffe werden profiliert. Die antifungale Potenz wird bestimmt und \u00f6ko-, zell- und phytotoxikologische Tests zur Umweltvertr\u00e4glichkeit durchgef\u00fchrt.<\/li>\n
  3. Die vielversprechendsten Bakterien und Naturstoffe werden in Pflanzen-Infektions-Experimenten getestet. Dies erm\u00f6glicht die Effektivit\u00e4t der biobasierten Produkte bei der Krankheitskontrolle zu bestimmen.<\/li>\n<\/ol>\n

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    Ergebnis<\/h2>\n

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    Das Projekt wird Wissen zu den metabolischen F\u00e4higkeiten von Bakterien liefern und einen Weg hin zu \u00f6kologisch nachhaltigen Biokontrollmitteln aufzeigen.<\/p>\n

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    Projektsteckbrief<\/h2>\n

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     <\/p>\n\n\n\n\n\n\n\n\n\n
    Projekttitel<\/td>\nProBioControl: Profilierung von Naturstoff-produzierenden Mikroorganismen f\u00fcr die Isolierung neuer antifungaler Naturstoffe und deren potentielle Anwendung als Biokontrollmittel<\/td>\n<\/tr>\n
    Laufzeit<\/td>\n02\/2023 \u2013 01\/2026<\/td>\n<\/tr>\n
    F\u00f6rderung<\/td>\nPromotions-Stipendienprogramm der Deutschen Bundesstiftung Umwelt<\/td>\n<\/tr>\n
    Stipendiatin<\/td>\nJoana Bauer<\/td>\n<\/tr>\n
    Kooperationspartner<\/td>\nJustus-Liebig-Universit\u00e4t Gie\u00dfen<\/td>\n<\/tr>\n
    Projekt Betreuer<\/td>\n\n

    Prof. Dr. Till Sch\u00e4berle (JLU\/IME)<\/p>\n

    Dr. Marius Spohn (IME)<\/p>\n<\/td>\n<\/tr>\n

    Ziele<\/td>\nStoffwechselprofilierung von antifungal aktiven Bakterien, zur potentiellen Anwendung als Biokontrollmittel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n

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    Ansprechpartner<\/h2>\n

    [\/et_pb_text][et_pb_divider color=“#FFBA5A“ divider_weight=“3px“ _builder_version=“4.16″ max_width=“80px“ height=“3px“ locked=“off“ global_colors_info=“{}“][\/et_pb_divider][\/et_pb_column][et_pb_column type=“2_5″ _builder_version=“4.16″ custom_padding=“|||“ global_colors_info=“{}“ custom_padding__hover=“|||“][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=“1_2,1_2″ _builder_version=“4.16″ min_height=“602.1px“ custom_margin=“-3px|auto|-3px|auto|true|“ custom_padding=“36px|||||“ locked=“off“ global_colors_info=“{}“][et_pb_column type=“1_2″ _builder_version=“4.16″ custom_padding=“|||“ global_colors_info=“{}“ custom_padding__hover=“|||“][et_pb_image src=“https:\/\/insekten-biotechnologie.de\/wp-content\/uploads\/2021\/02\/Till-Schaberle.jpg“ title_text=“Till-Schaberle“ _builder_version=“4.20.2″ _module_preset=“default“ background_enable_image=“off“ width=“50%“ custom_margin=“||17px|||“ custom_padding=“|49px|0px|||“ locked=“off“ global_colors_info=“{}“][\/et_pb_image][et_pb_text _builder_version=“4.20.2″ _module_preset=“default“ min_height=“167px“ locked=“off“ global_colors_info=“{}“]<\/p>\n

    Prof. Dr. Till Friedrich Sch\u00e4berle<\/h4>\n

    Abteilungsleiter \u00bbNaturstoffforschung\u00ab <\/span><\/p>\n

    Fraunhofer-Institut f\u00fcr Molekularbiologie und Angewandte Oekologie IME<\/span>
    Ohlebergsweg 12<\/span>
    35392\u00a0Gie\u00dfen<\/span><\/p>\n

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