LOEWE Center for
Insect Biotechnology
& Bioresources

Marius Spohn

Dr. rer. nat.

Group Leader

Phone: +49 641 972-19189

Email: marius.spohn@ime.fraunhofer.de

Room: A 211

Building: Fraunhofer IME - Neubau


since 2020 Group leader Molecular Microbiology in the Natural Product Department of Fraunhofer IME-BR
2016 - 2019 Research Scientist at Sanofi-Fraunhofer Center of Natural Product Research
2016 - 2017

Associated researcher at the University of Tuebingen.

Funded by the Innovation Grant of the Excellence Initiative Tuebingen.
01/2016 Completion of doctoral degree (summa cum laude)
12/2012 - 12/2015

PhD at the University of Tuebingen, IMIT, Dept. Microbiology/Biotechnology (Prof. W. Wohlleben).

“Exploiting Gene Regulation as an Approach to Identify, Analyze and Utilize the Biosynthetic Pathways of the Glycopeptide Ristomycin A and the Zincophore [S,S]-EDDS in Amycolatopsis japonicum"
2010-2012 Master of Science at the University of Tuebingen. (Biology / Specialization Biotechnology)
2007 - 2010 Bachelor of Science at the University of Tuebingen. (Biology)


  • Südwestmetall Nachwuchswissenschaftler-Förderpreis (2016)
  • Promotionspreis der Reinhold- und Maria-Teufel-Stiftung (2016)
  • Innovation Grants Life Sciences University of Tuebingen (2016)

Research Interests

  • Natural Product Biology: molecular biology of natural product biosynthesis and regulation, genome mining and metabolic engineering strategies.
  • Molecular and metabolic characterization of natural product producing microorganisms for applications in Pharma and Agro industry.
  • Bioactivity guided natural product discovery.


Edenhart S, Denneler M, Spohn M, Doskocil E, Kavšček M, Amon T, Kosec G, Smole J, Bardl B, Biermann M, Roth M, Wohlleben W, Stegmann E (2020) Metabolic engineering of Amycolatopsis japonicum for optimized production of [S,S]-EDDS, a biodegradable chelator. Metabolic Engineering, 60 , 148-156.
Hiebert, N, Kessel T, Skaljac M, Spohn M, Vilcinskas, A, Lee KZ (2020) The Gram-Positive Bacterium Leuconostoc pseudomesenteroides Shows Insecticidal Activity against Drosophilid and Aphid Pests. Insects, 11 (8)
Oberpaul M, Zumkeller CM, Culver T, Spohn M, Mihajlovic S, Leis B, Glaeser SP, Plarre R, McMahon DP, Hammann P, Schäberle TF, Glaeser J and Vilcinskas A (2020) High-Throughput cultivation for the selective isolation of Acidobacteria from termite nests. Frontiers in Microbiology, 11(597628)
Spohn M, Edenhart, S, Alanjary, M, Ziemert, N, Wibberg, D, Kalinowski, J, Niedermeyer, THJ, Stegmann, E, Wohlleben, W (2018) Identification of a novel aminopolycarboxylic acid siderophore gene cluster encoding the biosynthesis of ethylenediaminesuccinic acid hydroxyarginine (EDHA). Metallomics, 10 (5) (2018) , 722-734.
Adamek M, Spohn M, Stegmann E and Ziemert N (2017) Mining bacterial genomes for secondary metabolite gene clusters. Methods in Molecular Biology, 1520 , 23-47.
Spohn M, Wohlleben W, and Stegmann E (2016) Elucidation of the zinc dependent regulation in Amycolatopsis japonicum enabled the identification of the ethylenediamine‐disuccinate ([S,S]‐EDDS) genes. Environmental Microbiology , 1249 , 63.
Spohn M, Kirchner N, Kulik A, Jochim A, Wolf F, Münzer P, Borst O, Gross H, Wohlleben W, and Stegmann E (2014) Overproduction of ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417‐CF17. Antimicrobial Agents and Chemotherapy , 58 , 6185-6196.
Stegmann E, Albersmeier A, Spohn M, Gert H, Weber T, Wohlleben W, Kalinowski J, and Rückert C (2014) Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417‐CF17 (=DSM 44213T) producing (S,S)‐N,N'‐ethylenediaminedisuccinic acid. Journal of Biotechnology , 189 (C) , 46-47.