Holger Zorn
Prof. Dr.
Phone: +49 641 972-19130
Email: Holger.Zorn@lcb.chemie.uni-giessen.de
Room: B247
Building: HBR17
Vita
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Research Interests
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Publications
Fan R, Burghardt JP, Prell F, Zorn H, Czermak P
(2020)
Production and purification of fructo-oligosaccharides using an enzyme membrane bioreactor and subsequent fermentation with probiotic Bacillus coagulans.
Separation and Purification Technology,
251
(15)
https://doi.org/10.1016/j.seppur.2020.117291

Maheshwari G, Gessner DK, Meyer S, Ahlborn J, Wen G, Ringseis R, Zorn H, Eder K
(2020)
Characterization of the Nutritional Composition of a Biotechnologically Produced Oyster Mushroom and its Physiological Effects in Obese Zucker Rats.
Molecular Nutrition Food & Research,
64
(22)
, 2000591.

Maheshwari G, Ringseis R, Wen G, Gessner DK, Rost J, Fraatz MA, Zorn H, Eder K
(2020)
Branched-Chain Fatty Acids as Mediators of the Activation of Hepatic Peroxisome Proliferator-Activated Receptor Alpha by a Fungal Lipid Extract.
Biomolecules,
10 (9)
, 1259.

Meyer S, Gessner DK, Braune MS, Friedhoff T, Most E, Höring M, Liebisch G, Zorn H, Eder K, Ringseis R
(2020)
Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L. in growing pigs by transcriptomics, metabolomics and lipidomics.
Journal of Animal Science and Biotechnology,
11:20

Meyer S, Gessner DK, Maheshwari G, Röhrig J, Friedhoff T, Most E, Zorn H, Ringseis R, Eder K
(2020)
Tenebrio molitor Larvae Meal Affects the Cecal Microbiota of Growing Pigs.
Animals,
10
(7)
, 1151.

Meyer S, Schäfer L, Röhrig J, Maheshwari G, Most E, Zorn H, Ringseis R, Eder K, Gessner DK
(2020)
Supplementation of Sulfur-Containing Amino Acids or Essential Amino Acids Does Not Reverse the Hepatic Lipid-Lowering Effect of a Protein-Rich Insect Meal in Obese Zucker Rats.
Nutrients,
12
(4)
, 987.

Mika N, Zorn H, Rühl M
(2015)
Prolyl-specific peptidases for applications in food protein hydrolysis.
Applied Microbiology and Biotechnology,
99
(19)
, 7837–7846.

Shen T, Morlock G, Zorn H
(2015)
Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography.
Fungal Biology and Biotechnology,
2
(8)
, 1–7.

Zhuk TS, Goldmann M, Hofmann J, Pohl JCS, Zorn H
(2015)
Preparative aerobic oxidations with basidiomycetous enzymes: CH-functionalization of adamantane.
Journal of Molecular Catalysis B: Enzymatic,
122
, 87–92.

Cierpka K, Mika N, Lange MC, Zorn H, Czermak P, Salzig D
(2014)
Cell detachment by prolyl-specific endopeptidase from Wolfiporia cocos
American Journal of Biochemistry and Biotechnology,
10
(1)
, 14–21.

Kleofas V, Sommer L, Fraatz MA, Zorn H, Rühl M
(2014)
Fruiting body production and aroma profile analysis of Agrocybe aegerita cultivated on different substrates
Natural Resources,
5
(6)
, 233–240.

Bhandari DR, Shen T, Römpp A, Zorn H, Spengler B
(2013)
Analysis of cyathane type diterpenoids from Cyathus striatus and Hericium erinaceus by high-resolution MALDI MS imaging
Analytical and Bioanalytical Chemistry,
406
(3)
, 695–704.

Bosse AK, Fraatz MA, Zorn H
(2013)
Formation of complex natural flavors by biotransformation of apple pomace with basidiomycetes
Food Chemistry,
141
(3)
, 2952–2959.

Fraatz MA, Rühl M, Zorn H
(2013)
Food and Feed Enzymes
,
143
in Biotechnology of food and feed additives. Advances in Biochemical Engineering/Biotechnology,
Czermak P, Zorn H (Eds.)
, 229–256.
Springer:
Heidelberg

Liers C, Aranda E, Strittmatter E, Piontek K, Plattner DA, Zorn H, Ullrich R, Hofrichter M
(2013)
Phenol oxidation by DyP-type peroxidases in comparison to fungal and plant peroxidases
Journal of Molecular Catalysis B: Enzymatic,
103
, 41–46.

Liers C, Pecyna MJ, Kellner H, Worrich A, Zorn H, Steffen K, Hofrichter M, Ullrich R
(2013)
Substrate oxidation by dye-decolorizing peroxidases (DyPs) from wood- and litter-degrading agaricomycetes compared to other fungal and plant heme-peroxidases
Applied Microbiology and Biotechnology,
97
(13)
, 5839–5849.

Linke D, Matthes R, Nimtz M, Zorn H, Bunzel M , Berger RG
(2013)
An esterase from the basidiomycete Pleurotus sapidus hydrolyzes feruloylated saccharides
Applied Microbiology and Biotechnology,
97
(13)
, 7241–7251.

Mika N, Zorn H, Rühl M
(2013)
Insect derived enzymes – a treasure for white biotechnology and food biotechnology
,
in Yellow Biotechnology II. Advances in Biochemical Engineering/Biotechnology,
Vilcinskas A (Eds.)
, 1-17.
Springer:
Heidelberg

Prinz A, Hönig J, Schüttmann I, Zorn H, Zeiner T
(2013)
Purification and separation of laccases using aqueous two-phase extraction
Process Biochemistry,
49
(2)
, 335–346.

Schindler T, Mika N, Zorn H, Rühl M
(2013)
Characterization of insect associated ligninolytic enzymes for the industrial biotechnology.
Mitteilungen der Deutschen Gesellschaft für allgemeine und angewandte Entomologie,
19
, 31–35.
Schmidt K, Kunkel K, Szweda RT, Portz A, Fraatz MA, Zorn H
(2013)
Biotechnological production of norisoprenoid aroma compounds
,
in Carotenoid Cleavage Products. ACS Symposium Series,
Winterhalter P, Eberle SE (Eds.)
, 157–168.
American Chemical Society:
Washington, DC

Schüttmann I, Bouws H, Szweda RT, Suckow M, Czermak P, Zorn H
(2013)
Induction, characterization, and heterologous expression of a carotenoid degrading versatile peroxidase from Pleurotus sapidus
Journal of Molecular Catalysis B: Enzymatic,

Szweda RT, Schmidt K, Zorn H
(2013)
Bleaching of colored whey and milk by a multiple enzyme system
European Food Research and Technology,
237
(3)
, 377–384.

Weidmann V, Schaffrath M, Zorn H, Rehbein J, Maison W
(2013)
Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus - conversion of selected spirocyclic terpenoids and computational analysis
Beilstein Journal of Organic Chemistry,
9
, 2233-2241.

Basiewicz M, Weiß M, Kogel K-H, Langen G, Zorn H, Zuccaro A
(2012)
Molecular and phenotypic characterization of Sebacina vermifera strains associated with orchids, and the description of Piriformospora williamsii sp. nov.
Fungal Biology 116(2),
, 204-213.

Lenhart K, Bunge M, Ratering S, Neu TR, Schüttmann I, Greule M, Kammann C, Schnell S, Müller C, Zorn H, Keppler F
(2012)
Evidence for methane production by saprotrophic fungi
Nature Communications,
3
, 1046.

Prinz A, Zeiner T, Vössing T, Schüttmann I, Zorn H, Górak A
(2012)
Experimental Investigation of Laccase Purification Using Aqueous Two-Phase Extraction
Chemical Enginieering Transactions,
27
, 1–6.

Rickert A, Krombach V, Hamers O, Zorn H, Maison W
(2012)
Enzymatic allylic oxidations with a lyophilisate of the edible fungus Pleurotus sapidus
Green Chemistry,
14
(3)
, 639–644.

Merz J, Burghoff B, Zorn H, Schembecker G
(2011)
Continuous foam fractionation: Performance as a function of operating variables
Separation and Purification Technology 82,
, 10-18.

Schmidt K, Fraatz MA, Riemer SJL, Zelena K, Linke D, Berger RG, Zorn H
(2011)
A novel oxygenase from the basidiomycete Pleurotus sapidus oxidizes valencene to nootkatone
In: Hofmann T, Meyerhof W, Schieberle P (Eds) Advances and challenges in flavor chemistry & biology. Deutsche Forschungsanstalt für Lebensmittelchemie, München,
, 235-241.
Berger RG, Krings U, Zorn H
(2010)
Biotechnological flavour generation
In: Taylor A, Linforth RST (Eds) Food Flavour Technology, Second Edition. Wiley-Blackwell, Chichester, UK,
, 89-126.
Fraatz MA, Zorn H
(2010)
Fungal flavors
In: Esser K, Hofrichter M (Eds) The Mycota X: Industrial applications, Springer, Heidelberg,
, 249-268.
Krügener S, Krings U, Zorn H, Berger RG
(2010)
A dioxygenase of Pleurotus sapidus transforms (+)-valencene regio-specifically to (+)-nootkatone via a stereo-specific allylic hydroperoxidation
Bioresource Technology 101(2),
, 457-462.

Merz J, Zorn H, Burghoff B, Schembecker G
(2010)
Purification of a fungal cutinase by adsorptive bubble separation: A statistical approach
Colloids and Surfaces A: Physicochemical and Engineering Aspects 382(1-3),
, 81-87.

Verheyden K, Noppe H, Zorn H, Van Immerseel F, Vanden Bussche J, Wille K, Bekaert K, Janssen CR, De Brabander HF, Vanhaecke L
(2010)
Endogenous boldenone-formation in cattle: Alternative invertebrate organisms to elucidate the enzymatic pathway and the potential role of edible fungi on cattle's feed
The Journal of Steroid Biochemistry and Molecular Biology 119(3-5),
, 161-170.

Zelena K, Hardebusch B, Hülsdau B, Berger RG, Zorn H
(2010)
Generation of norisoprenoid flavours from carotenoids by fungal peroxidases
In: Blank I, Wüst M, Yeretzian C (Eds) Expression of Multidisciplinary Flavour Science, Proc. 12th Weurman Flavour Symposium. ZHAW, Zürich,
, 336-339.
Fraatz MA, Berger RG, Zorn H
(2009)
Nootkatone — a biotechnological challenge
Applied Microbiology and Biotechnology 83(1),
, 35-41.

Fraatz MA, Riemer SJL, Stöber R, Kaspera R, Nimtz M, Berger RG, Zorn H
(2009)
A novel oxygenase from Pleurotus sapidus transforms valencene to nootkatone
Journal of Molecular Catalysis B: Enzymatic 61(3-4),
, 202-207.

Krings U, Lehnert N, Fraatz MA, Hardebusch B, Zorn H, Berger RG
(2009)
Autoxidation versus Biotransformation of α-Pinene to Flavors with Pleurotus sapidus: Regioselective Hydroperoxidation of α-Pinene and Stereoselective Dehydrogenation of Verbenol
Journal of Agricultural and Food Chemistry 57(21),
, 9944-9950.

Krügener S, Zelena K, Zorn H, Nimtz M, Berger RG
(2009)
Heterologous expression of an extracellular lipase from the basidiomycete Pleurotus sapidus
Journal of Molecular Catalysis B: Enzymatic 57(1-4),
, 16-21.

Linke D, Nimtz M, Berger RG, Zorn H
(2009)
Separation of Extracellular Esterases from Pellet Cultures of the Basidiomycete Pleurotus sapidus by Foam Fractionation
Journal of the American Oil Chemists' Society 86(5),
, 437-444.

Merz J, Schembecker G, Riemer SJL, Nimtz M, Zorn H
(2009)
Purification and identification of a novel cutinase from Coprinopsis cinerea by adsorptive bubble separation
Separation and Purification Technology 69(1),
, 57-62.

Pühse M, Szweda RT, Ma Y, Jeworrek C, Winter R, Zorn H
(2009)
Marasmius scorodonius extracellular dimeric peroxidase — exploring its temperature and pressure stability
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1794(7),
, 1091-1098.

Zelena K, Hardebusch B, Hülsdau B, Berger RG, Zorn H
(2009)
Generation of Norisoprenoid Flavors from Carotenoids by Fungal Peroxidases
Journal of Agricultural and Food Chemistry 57(21),
, 9951-9955.

Zelena K, Krügener S, Lunkenbein S, Zorn H, Berger RG
(2009)
Functional expression of the lipase gene Lip2 of Pleurotus sapidus in Escherichia coli
Biotechnology Letters 31(3),
, 395-401.

Zelena K, Zorn H, Nimtz M, Berger RG
(2009)
Heterologous expression of the msp2 gene from Marasmius scorodonius
Archives of Microbiology 191(5),
, 397-402.

Berger RG, Zorn H
(2008)
Biotechnology of flavours – recent progress
In: Koutinas A, Pandey A, Larroche C (Eds) Current topics on bioprocesses in food industry, Vol II. Asiatech Publishers, New Delhi,
, 30-42.
Bouws H, Wattenberg A, Zorn H
(2008)
Fungal Secretomes — Nature's toolbox for white biotechnology
Applied Microbiology and Biotechnology 80(3),
, 381-388.

Fleischmann P, Zorn H
(2008)
Enzymic pathways for formation of carotenoid cleavage products
In: Britton G, Liaaen-Jensen S, Pfander H (Eds) Carotenoids, Vol. 4: Natural Functions. Birkhäuser, Basel,
, 341-366.
Scheibner M, Hülsdau B, Zelena K, Nimtz M, de Boer L, Berger RG, Zorn H
(2008)
Novel peroxidases of Marasmius scorodonius degrade β-carotene
Applied Microbiology and Biotechnology 77(6),
, 1241-1250.

Taupp D, Nimtz M, Berger RG, Zorn H
(2008)
Stress response of Nidula niveo-tomentosa to UV-A light
Mycologia 100(4),
, 529-538.

Zorn H, Taupp DE, Hülsdau B, Scheibner M, Fraatz MA, Berger RG
(2008)
"Bioflavours" – an excursion from the garlic mushroom to raspberry aroma
In: Hofmann T, Meyerhof W, Schieberle P (Eds) Recent highlights in flavor chemistry and biology. Deutsche Forschungsanstalt für Lebensmittelchemie, München,
, 203-209.
Becker T, Breithaupt D, Doelle HW, Fiechter A, Griensven M, Kasper C, Luetz S, Poertner R, Schlegel H-G, Sell D, Shimizu S, Stahl F, Suck K, Ulber R, Wegener J, Wuerges K, Yamada H, Zorn H
(2007)
Biotechnology
In: Ullmann's Biotechnology and Biochemical Engineering. Wiley-VCH, Weinheim, Volume 1,
, 3-155.
Linke D, Zorn H, Gerken B, Parlar H, Berger RG
(2007)
Laccase isolation by foam fractionation — new prospects of an old process
Enzyme and Microbial Technology 40(2),
, 273-277.

Ruiz-Dueñas FJ, Aguilar A, Martínez MJ, Zorn H, Martínez AT
(2007)
Gene cloning, heterologous expression, in vitro activation and catalytic properties of a versatile peroxidase
Biocatalysis and Biotransformation 25(2-4),
, 276-285.

Wu S, Zorn H, Krings U, Berger RG
(2007)
Volatiles from submerged and surface cultured beefsteak fungus, Fistulina hepatica
Flavour and Fragrance Journal 22(1),
, 53-60.

dos Prazeres JN, Simiquelli AP, Pastore GM, Linke D, Zorn H, Nimtz M, Berger RG
(2007)
Recovery of extracellular alkaline lipases of Fusarium spec. by foam fractionation
Fresenius Environmental Bulletin 16(11),
, 1503-1508.
Gerken BM, Nicolai A, Linke D, Zorn H, Berger RG, Parlar H
(2006)
Efficient enrichment of laccase C using continuous foam fractionation
Separation and Purification Technology 49(3),
, 291-294.

Krings U, Johansson L, Zorn H, Berger RG
(2006)
In vitro DNA protective activity of roasted wheat germ and fractions thereof
Food Chemistry 97(4),
, 712-718.

Krings U, Zorn H, Berger RG
(2006)
Innovative mass spectrometric tools for the structural elucidation of flavour compounds
In: Bredie WLP, Petersen MA (Eds) Flavour Science - recent advances and trends. Elsevier, Amsterdam,
, 573-576.
Taskova RM, Zorn H, Krings U, Bouws H, Berger RG
(2006)
A Comparison of Cell Wall Disruption Techniques for the Isolation of Intracellular Metabolites from Pleurotus and Lepista sp.
Zeitschrift für Naturforschung 61c(5/6),
, 347-350.

Zorn H, Fischer-Zorn M
(2006)
Lebensmittelhygiene und -toxikologie
In: Jenik H, Kraft M, Miko M, Schulz R-J (Eds) Leitfaden Ernährungsmedizin. Urban & Fischer, München,
, 147-181.
Berger RG, Krings U, Zorn H
(2005)
Biotechnology Solutions to Flavour Production
In: Hofmann T, Rothe M, Schieberle P (Eds) State-of-the-Art in Flavour Chemistry and Biology. Deutsche Forschungsanstalt für Lebensmittelchemie, Garching,
, 223-233.
Gerken BM, Wattenbach C, Linke D, Zorn H, Berger RG, Parlar H
(2005)
Tweezing-adsorptive bubble separation - a novel analytical method for the selective and high enrichment of metalloenzymes
Analytical Chemistry 77(19),
, 6113-6117.

Linke D, Bouws H, Peters T, Nimtz M, Berger RG, Zorn H
(2005)
Laccases of Pleurotus sapidus: Characterisation and Cloning
Journal of Agricultural and Food Chemistry 53(24),
, 9498-9505.

Linke D, Zorn H, Gerken B, Parlar H, Berger RG
(2005)
Foam fractionation of exo-lipases from growing fungus Pleurotus sapidus
Lipids 40(3),
, 323-327.

Wu S, Krings U, Zorn H, Berger RG
(2005)
Volatile compounds from the fruiting bodies of beefsteak fungus Fistulina hepatica (Schaeffer: Fr.) Fr.
Food Chemistry 92(2),
, 221-226.

Wu S, Zorn H, Krings U, Berger RG
(2005)
Characteristic Volatiles from young and aged fruiting bodies of wild Polyporus sulfureus(Bull.: Fr.) Fr.
Journal of Agricultural and Food Chemistry 53(11),
, 4524-4528.

Zorn H, Bouws, H, Takenberg M, Nimtz M, Getzlaff R, Breithaupt D, Berger RG
(2005)
An extra-cellular carboxylesterase from the basidiomycete Pleurotus sapidus hydrolyses xanthophyll esters
Biological Chemistry 386(5),
, 435-440.
Zorn H, Peters T, Nimtz M, Berger RG
(2005)
The Secretome of Pleurotus sapidus
Proteomics 5(18),
, 4832-4838.

Berger RG, Zorn H
(2004)
Flavors and Fragrances
In: Tkacz J, Lange L (Eds) Advances in fungal biotechnology for industry, agriculture, and medicine. Kluwer Academic/Plenum Publishers, New York,
, 341-358.
Ramani B, Zorn H, Papenbrock J
(2004)
Quantification and fatty acid profiles of sulfolipids in two halophytes and a glycophyte grown under different salt concentrations
Zeitschrift für Naturforschung 59(11-12),
, 835-842.
Schueler M, Zorn H, Slawin AMZ, Berger RG
(2004)
Synthesis of α‐Hydroxy Ketones from Terpene Aldehydes
Synthetic Communications 34(14),
, 2591-2600.
Zorn H, Neuser F, Berger RG
(2004)
Degradation of α-pinene oxide and [²H7]-2,5,6-trimethyl-hept-(2E)-enoic acid by Pseudomonas fluorescens NCIMB 11761
Journal of Biotechnology 107(3),
, 255-263.

Rabe S, Krings U, Zorn H, Berger RG
(2003)
Lipid molarity affects liquid/liquid aroma partitioning and its dynamic release from oil/water emulsions
Lipids 38(10),
, 1075-1084.

Zorn H, Breithaupt DE, Takenberg M, Schwack W, Berger RG
(2003)
Enzymatic hydrolysis of carotenoid esters of marigold flowers (Tagetes erecta L.) and red paprika (Capsicum annuum L.) by commercial lipases and Pleurotus sapidus extracellular lipase.
Enzyme and Microbial Technology 32(5),
, 623-628.

Zorn H, Fischer-Zorn M, Berger RG
(2003)
A labeling study to elucidate the biosynthesis of 4-(4-hydroxyphenyl)-butan-2-one (raspberry ketone) by Nidula niveo-tomentosa
Applied and Environmental Microbiology 69(1),
, 367-372.

Zorn H, Langhoff S, Scheibner M, Berger RG
(2003)
Cleavage of β,β-carotene to flavor compounds by fungi.
Applied Microbiology and Biotechnology 62(4),
, 331-336.

Zorn H, Langhoff S, Scheibner M, Nimtz M, Berger RG
(2003)
A peroxidase from Lepista irina cleaves β,β-carotene to flavor compounds
Biological Chemistry 384(7),
, 1049-1056.

Zorn H, Schüler M, Berger RG
(2003)
Pyruvate decarboxylase catalyzed formation of terpenoid α-hydroxy ketones
Biocatalysis and Biotransformation 21(6),
, 341-347.

Berger RG, Krings U, Zorn H
(2002)
Biotechnological flavour generation
In: Taylor A (ed.) Food Flavour Technology. Sheffield Academic Press, Sheffield,
, 60-104.
Zorn H, Berger RG
(2002)
Flavors and fragrances from plants
In: Oksman-Caldentey K-M, Barz WH (Eds) Plant Biotechnology and Transgenic Plants. Marcel Dekker, New York,
, 323-346.
Neuser F, Zorn H, Berger RG
(2000)
Formation of aliphatic and aromatic α-hydroxy ketones by Zygosaccharomyces bisporus.
Zeitschrift für Naturforschung,
55c
(7/8)
, 560-568.

Neuser F, Zorn H, Berger RG
(2000)
Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurence in sherry and soy sauce.
Journal of Agricultural and Food Chemistry 48(12),
, 6191-6195.

Neuser F, Zorn H, Richter U, Berger RG
(2000)
Purification, characterisation and cDNA sequencing of pyruvate decarboxylase from Zygosaccharomyces bisporus
Biological Chemistry 381(4),
, 349-353.

Jahn C, Zorn H, Petersen A, Schwack W
(1999)
Structure-specific detection of plant cuticle bound residues of chlorothalonil by ELISA.
Pesticide Science 55(12),
, 1167-1176.

Zorn H
(1997)
Verhalten und Reaktivität des Fungicids Chlorothalonil auf Fruchtoberflächen unter besonderer Beachtung der photochemischen Bildung gebundener Rückstände
Berichte aus der Chemie, Shaker Verlag, Herzogenrath,